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PEPCID may be taken with or without food [see Clinical Pharmacology (12. Prescription medications for this condition are Tagamet, Pepcid, Axid and Zantac. It starts to relieve heartburn in 15–30 minutes, and controls acid all day or all night. 3)] 1 Starts to relieve heartburn in 15-30 minutes. 43 Buy Online Find Locally Select another retailer Overview From the #1 doctor recommended acid reducer brand, Original Strength PEPCID AC ® is a famotidine tablet that works fast and lasts to prevent and relieve occasional heartburn. Applies only to oral form of both agents. Pepcid also comes in prescription form as 20 milligrams or 40 milligrams of famotidine. Maintenance dose: 20 mg orally once a day at bedtime. A headache is the most common side more Prescription only. Pepcid (famotidine) Prescription and OTC Famotidine is an acid-suppressing agent that may be used to treat a wide range of gastric-acid-related disorders including gastric ulcers, heartburn, and GERD. 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